The focus of PU04 is the metabolism of carbohydrates. The material for study is available on-line and may be found in Textbook of Biochemistry with Clinical Correlations edited by Thomas M. Devlin (the Wiley web site has links to additional resources).
Metabolism at a Glance by J. G. Salway is available for $29.95 and is an excellent approach to the metabolism covered in the Problem Units. Blackwell Science Inc. has other titles in their "at a Glance" series.
Be sure to check with the MRC Web site for access to additional curricular materials.
For those of you using the recommended text, material may be found in (but not limited to nor in the listed order of) the following chapters:
| Chapter 6 | Bioenergetics and Oxidative Metabolism |
| Chapter 7 | Carbohydrate Metabolism I: Major Metabolic Pathways and Their Control |
| Chapter 8 | Carbohydrate Metabolism II: Special Pathways |
| Chapter 13 | Metabolic Interrelationships |
| Chapter 26 | Digestion and Absorption of Basic Nutritional Constituents |
| Chapter 28 | Principles of Nutrition II: Micronutrients |
| Appendix | Review of Organic Chemistry |
|
p. 318 |
| Fig
7.53 should indicate that the glucosidase activity of
the debranching enzyme removes the remaining alpha-1,6-linked glucosyl residue at the bottom of the figure. |
p. 318 |
| Clinical
Correlation 8.7 contains the incorrect structure for a typical Asn-GlcNac oligosaccharide. The correct structure appears at the bottom of Clinical Correlation 8.9 on p. 352. (correct version) |
p. 349 |
| Clinical
Correlation 8.9 contains incorrect structures for dermatan sulfate
and heparan sulfate. The correct structure appear at the bottom of Clinical Correlation 8.7 on p. 349. (correct version) |
p. 352 |
I have made available RealAudio files prepared for the 1999-2000 curriculum.
Click on lecture to listen |
Click on link for full description |
| Lecture 1 (11/8/99) 50 min | Course introduction and carbohydrates |
| Lecture 2 (11/10/99) 51 min | Energy overview and glycolysis |
| Lecture 3 (11/15/99) 48 min | Regulatory features of glycolysis and gluconeogenesis |
| Lecture 4 (11/17/99) 48 min | Metabolism
of other monosaccharides, glycogenesis and glycogenolysis and regulatory features of these pathways |
| Lecture 5 (11/29/99) 32 min | Pentose phosphate pathway and Pacing Quiz |
|
|
|
| Lecture 6 (1/04/00) 51 min | Sugar
interconversions, complex carbohydrates, glycoproteins and proteoglycans |
| Lecture 7 (1/06/00) 45 min | Energy-rich
compounds, acetyl-CoA, citric acid cycle and regulatory features |
| Lecture 8 (1/10/00) 48 min | Electron transport chain |
| Lecture 9 (1/11/00) 44 min | Oxidative
phosphorylation, nutritional features of and defects in carbon metabolism |
Problem Unit 4 is available in the form of a pdf (Portable Document Format) document which can be either read online or downloaded from this web site. The documents can be read on both PC's and Mac's with Adobe Acrobat Reader.
| Grading and pacing quiz, Salway resource on metabolism | p. 3 |
| Objectives 6, 7, and 10 | p. 7 |
| Objective 15 | p. 8 |
| GLUT transporter family including tissue distribution | pp. 15-16 |
| NADH described as hydrogen carrier | p. 20 |
| FADH2 described as hydrogen carrier | p. 36 |
| Energy source (ATP) for gluconeogensis | p. 25 |
| Glycogen synthesis expanded to include role of glycogenin and glycan primer | p. 27 |
| Maximum yield of ATP per 0.5 O2 | pp. 48-49 |
| How much ATP really forms from complete oxidation of glucose? | pp. 54-55 |
| Modern P/O ratios for glycerol phosphate and malate-aspartate shuttles | pp. 57-58 |
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