C2000 Resources

Problem-Based Learning Modules

Created by Eric C. Niederhoffer, Ph.D.

Associate Professor, Biochemistry & Molecular Biology

Copyright 2000- , E.C. Niederhoffer. All Rights Reserved.
All trademarks and copyrights are the property of their respective owners.


The Biochemistry and Molecular Biology Problem-Based Learning Resources page is designed to support the three objective areas defined by the curriculum.

Check back often for resource page updates! [External links to resources are added (by me) and deleted (by them).]

  • Self-direct learning and articulation
  • Reasoning
  • Interpersonal and group skills

For more information concerning these objectives see PBL: A Student Guide.

As your tutor group works through a Problem-Based Learning Module, learning issues (LI) will be developed. Some groups (as well as some of the cases) are better at this than others. Some groups (and some of the cases) lose focus from time-to-time and important issues are lost in the shuffle.

In order to foster your ability to develop LI and build a knowledge base in biochemistry, including cell and molecular biology, I have created unit LI grids, featured topics, major points, and correlated readings. One can build a foundation by learning about specific topics or by asking questions pertinent to each case. You should note that many of the potential LI appear in multiple cases and across units. You have multiple opportunities to encounter these topics, so don't think that you must completely cover them with any particular case. Note that the link to a PBLM resource page will be activated as tutor groups process that particular case. If you try to open a page too early, it will automatically transfer back to the main unit page.

Y1 Units

  • Cardiovascular/Respiratory/Renal (CRR)
  • Sensorimotor Systems & Behavior (SSB)
  • Endocrine/Reproduction/Gastrointestinal (ERG)

General Resources

I recommend the following textbooks for biochemistry and cell and molecular biology:

  • Devlin, T. M. (ed.). 2006. Textbook of biochemistry with clinical correlations, 6th ed. John Wiley & Sons, Inc., New York. This is very good for most of what you need.
  • Karp, G. (ed.). 2005. Cell and molecular biology: concept and experiments, 4th ed. John Wiley & Sons, Inc., New York. This covers cell biology topics not found in Devlin.
  • Nelson, D. L., and M. M. Cox. (ed.). 2008. Lehninger principles of biochemistry, 5th ed. Worth, New York. This is very good for most of what you need but lacks the clinical correlations found in Devlin.
  • Salway, J. G. 2006. Medical biochemistry at a glance, 2nd ed. Blackwell Science, Malden, Mass. This is very good for general principles and topics, and metabolic pathways and regulation. Good focused clinical correlations.
  • Salway, J. G. 2004. Metabolism at a glance, 3rd ed. Blackwell Science, Malden, Mass. This is very good for learning metabolic pathways and regulation, probably the best that I have seen but is physical large in size. Some students find the illustrations too complicated.

The following textbooks are also useful:

  • Braunwald, E., A. S. Fauci, D. L. Kasper, S. L. Hauser, D. L. Longo, and J. L. Jameson (ed.). 2001. Harrison's principles of internal medicine, 15th ed. McGraw-Hill, Inc., New York.
  • Scriver, C. R., A. L. Beaudet, D. Valle, W. S. Sly, B. Childs, K. Kinzler, and B. Vogelstein (ed.). 2001. The metabolic and molecular bases of inherited disease, 8th ed. McGraw-Hill, Inc., New York.

 Correlated readings for Clinical Laboratory Tests

The following may be quite useful also:

For those of you interested in molecular structures, visit the PDB Molecule of the Month. Structures and descriptions that you may be interested in include the following:

 actin  myosin
 alcohol dehydrogenase  nucleosome
 aminoacyl-tRNA synthetases  p53
 collagen  pepsin
 cyclooxygenase  potassium channels
 cytochrome c oxidase  restriction enzymes
 DNA polymerase  ribosome
 glycogen phosphorylase  serum albumin
 insulin  thrombin
 myoglobin  transfer RNA

A collection of macromolecules (proteins and nucleic acids) is available at "Chime Square."

Biochemistry Pearls

Most of what you will encounter in biochemistry has as its foundation the concept of molecular interactions. How do molecules get together, stay together, carry out reactions, define identity, and transduce signals? It would be wise to have an understanding of the building blocks including amino acids, carbohydrates, lipids, and nucleic acids.

Remember, learning content is important in developing an understanding of concepts, both of which serve as a proxy for reflecting your ability to manage and care for patients. As the year progresses, you should be building an effective reading knowledge of biochemistry, including cell and molecular biology. By the end of Y1, you will have encountered a wealth of pertinent information.

 

Biochemistry and Molecular Biology Home Page

Submit your questions and comments to the following:
eniederhoffer@siumed.edu